Originally trained as a neurophysiologist, I currently use Biochemistry, Molecular Biology and Proteomics to investigate the molecular nature of visual transduction as it relates to a broader area of signal transduction.

Association for Research in Vision and Ophthalmology
Association of College and University Biology Educators
Cumberland Biological Transport Group
National Science Teachers Association

I am currently interested in the functional significance of subunit stoichiometry and heterogeneity of a GTP-binding protein named Transducin, a cornerstone of the cyclic nucleotide cascade that underlies our ability to see. I am trying to determine how differences in Transducin stoichiometry affect its function. I am also examining the effect of different post-translational modifications of the beta subunit of Transducin on its function, including its interactions with other subunits, proteins and the photoreceptor disc membrane. I am also collaborating with other investigators in the analysis of proteins as biomarkers for cellular and tissue injury precipitated by environmental stressors.

• BIOL N100   Contemporary Biology
• BIOL N212   Human Biology 1
• BIOL N213   Human Biology Lab 1
• BIOL N214   Human Biology 2
• BIOL N215   Human Biology Lab 2
• BIOL N217   Human Physiology
• BIOL N261   Human Anatomy
• BIOL K101   Introduction to Biology I
• BIOL K103   Introduction to Biology II
• BIOL K295   Independent Study
• BIOL K324   Cell Biology
• BIOL K493   Independent Research
• BIOL K494   Senior Research Thesis
• BIOL 698   Research M.S. Thesis

I received a B.A. in Biology from Indiana University and a Ph.D. in Neurobiology from Purdue University. I subsequently completed an NIH Postdoctoral Fellowship at the Yale University School of Medicine.

I am currently the Head of the Division of Science. I am Past-President of the IUPUC Faculty Senate. I chair the IUPUC Animal Use and Care Committee. I am a member of the IUPUC Grievance Committee, the IUPUC Promotion and Tenure Committee, and several divisional search and screen committees. I am the IUPUC Radiation Safety Officer (NRC Material License 13-26370-01). I am also a member of the following IUPUI committees: IUPUI Faculty Council, Faculty Council Technology Committee, IUPUI Promotion and Tenure Committee. I serve on the Board of Directors and am the webmaster for the Cumberland Biological Transport Group. I also serve on the editorial board of the Journal of College Biology Teaching.

Mason, S.B., Clack, J.W., Ringham, H.N., Thomas, A., Witten, M.L., Witzmann, F.A. Lung Protein Expression Following Acute Formalin Exposure – Effect of The Substance P Derivative Sar⁹, Met (O₂)¹¹-Substance P. Toxicological Pathology: Under Review.

Clack, J.W., Affinity of Transducin for Photoactivated Rhodopsin: Dependence on Nucleotide Binding State. Biochemistry and Molecular Biology Reports 40: 548-553, 2008.

Clack, J.W., Springmeyer, M., Clark, C., Witzmann, F.A. Analysis of Transducin Subunit Stoichiometry and Cellular Distribution. Cell Biology International 30: 829-35, 2006.

Clack, J.W., Juhl, M., Rice, C.A., Li, J., and Witzmann, F.A. Proteomic Analysis of Transducin Beta Subunit Structural Heterogeneity. Electrophoresis 24: 3493-3499, 2003.

Witzmann, F.A., Clack, J.W., Geiss, K., Hussain, S., Juhl, M.J., Rice, C.M., and Wang, C. Proteomic Evaluation of Cell Preparation Methods in Primary Hepatocyte Cell Culture. Electrophoresis 23: 2223-2232, 2002.

Clack, J.W., Computer Enhancement Of Undergraduate Biology Laboratories: Activities and Findings. Technical Report, National Science Foundation Project Database, July 2000.

2006	Recipient of Meritorious Achievement Award, Cumberland Biological Transport Group, American Physiology Association Affiliate.
2004	Recipient of Indiana University Trustees Teaching Award, Indiana University – Purdue University Columbus.
1982	Recipient of NIH posdoctoral traineeship, Yale University School of Medicine, New Haven, CT.
1980	Recipient of NIH predoctoral traineeship, Purdue University, West Lafayette, IN.
1977	Recipient of David Ross Fellowship, Purdue University, West Lafayette, IN.

“Proteomic Analysis of Structural and Functional Heterogeneity of Photoreceptor G Proteins,” IUPUI Office for Professional Development Grant-in-Aid. Total funds, $6,000.

“Analysis of Transducin Beta Subunit Heterogeneity,” Fight-For-Sight Research Division of Prevent Blindness America. Total funds, $11,970.

“Computer Enhancement of Undergraduate Biology Laboratory Experience,” National Science Foundation Program 7428, CCLI-Adaptation and Implementation. Total funds, $39,990.

“Integration of Molecular Biology Techniques into General Introductory Biology,” Columbus Teachers Network. Total funds, $1,200.

"Synthesis and Purification of 2'-O-(4-benzoyl)benzoylguanosine 3',5' cyclic monophosphate and 2'-O-(4-benzoyl)benzoyladenosine 3',5' cyclic monophosphate For Use as Phosphodiesterase Inhibitors and Anti-Glaucoma Agents," Indiana Lions Alliance. Total funds, $20,689.

"Studies of Photoreceptor Calcium Binding Proteins and Anti Glaucoma Agents," IUPUI Office of Faculty Development. Total funds, $5,830.

"Studies of Opsin cGMP-gated single channel activity," NIH Grant EY 07523-01A. Total funds, $468,451.

"Anti-glaucoma activity of phosphodiesterase inhibitors," Connecticut Seed Ventures. Total funds, $224,800.

I have served as a judge for many science fairs, from local elementary schools to the Indiana State Science Fair to the Intel International Science and Engineering Fair. I have given multiple talks to local K-12 schools. I have been an invited lecturer on topics such as evolution and neuroscience in local high schools.